Kirstie Alley
Mollie Ubriacco
John Travolta
James Ubriacco
Bruce Willis
Mikey (voice)
Roseanne Barr
Julie (voice)
Gilbert Gottfried
Joey
Damon Wayans
Eddie (voice)
Mel Brooks
Mr. Toilet Man (voice)
Olympia Dukakis
Rosie
Elias Koteas
Stuart
Twink Caplan
Rona
Lorne Sussman
Mikey
Megan Milner
Julie
Danny Pringle
Eddie
Don S. Davis
Dr. Fleischer
Rick Avery
Burglar