Rick Moranis
Seymour Krelborn
Ellen Greene
Audrey
Vincent Gardenia
Mushnik
Levi Stubbs
Audrey II (voice)
Steve Martin
Orin Scrivello D.D.S.
Tichina Arnold
Crystal
Michelle Weeks
Ronnette
Tisha Campbell-Martin
Chiffon
Jim Belushi
Patrick Martin
John Candy
Wink Wilkinson
Christopher Guest
The First Customer
Bill Murray
Arthur Denton
Stan Jones
Narrator (voice)
Bertice Reading
'Downtown' Old Woman
Ed Wiley
'Downtown' Bum #1
Alan Tilvern
'Downtown' Bum #2
John Scott Martin
'Downtown' Bum #3
Vincent Wong
Chinese Florist
Mak Wilson
Doo-Wop Street Singer
Danny Cunningham
Doo-Wop Street Singer
Danny John-Jules
Doo-Wop Street Singer
Paul Swaby
Doo-Wop Street Singer
Mildred Shay
Second Customer
Melissa Wiltsie
Third Customer
Kevin Scott
Fourth Customer
Barbara Rosenblat
Fifth Customer
Adeen Fogle
Radio Station Assistant
Kelly Huntley
Audrey & Seymour's Kid
Paul Reynolds
Audrey & Seymour's Kid
Miriam Margolyes
Dental Nurse
Abbie Dabner
Boy Patient
Francis Dux
Second Patient
Peter Whitman
Patient on Ceiling
Heather Henson
Girl Patient
Judith Morse
Girl's Mother
Bob Sherman
Agent
Doreen Hermitage
'Life' Magazine Lady
Kerry Shale
Her Assistant
Robert Arden
Network Exec #1
Stephen Hoye
Network Exec #2
Bob Sessions
Network Exec #3
Michael Shannon
Television Reporter
Jill Goldston
Frantic Shopper (uncredited)