Natalie Lander
Krissy Holdout (voice)
Kate Micucci
Velma Dinkley (voice)
Matthew Lillard
Shaggy Rogers (voice)
Grey DeLisle
Daphne Blake (voice)
Iqbal Theba
Dr. Najib (voice)
Frank Welker
Scooby-Doo / Fred Jones (voice)
Kate Higgins
Brenda (voice)
Hynden Walch
Mitzi Capaletto (voice)
Jeff Bennett
Deputy / Museum Guide (voice)
Kevin Michael Richardson
Sheriff (voice)
Tom Kenny
Rob Holdout (voice)
Jack McBrayer
Police Officer (voice)
Fred Tatasciore
Dwight Monkfish (voice)
Josh Keaton
Tommie / Chad Holdout (voice)