Scott Wolf
Scamp (speaking) (voice)
Alyssa Milano
Angel (speaking) (voice)
Chazz Palminteri
Buster (speaking) (voice)
Jeff Bennett
Tramp / Jock / Trusty / Dogcatcher (voice)
Jodi Benson
Lady (voice)
Bill Fagerbakke
Mooch (voice)
Mickey Rooney
Sparky (voice)
Bronson Pinchot
Francois (voice)
Cathy Moriarty
Ruby (voice)
Mary Kay Bergman
Si (voice)
Debi Derryberry
Annette (voice)
Barbara Goodson
Darling (voice)
Nick Jameson
Jim Dear (voice)
Tress MacNeille
Aunt Sarah / Am (voice)
Rob Paulsen
Otis (voice)
Kath Soucie
Collette / Danielle (voice)
Frank Welker
Reggie (voice)
April Winchell
Mrs. Mahoney (voice)
Jim Cummings
Tony (voice)
Michael Gough
Joe (voice)
Jess Harnell
Buster (singing voice) (uncredited)
Andrew McDonough
Junior (voice)