Debi Derryberry
Jimmy Neutron / Alien Actress / Alien Woman (voice)
Rob Paulsen
Carl Wheezer/Mr. Wheezer/Mrs. Wheezer/Test Pilot/Announcer (voice)
Jeffrey Garcia
Sheen Estevez / Army Guard (voice)
Frank Welker
Goddard (voice)
Carolyn Lawrence
Cindy Vortex (voice)
Crystal Scales
Libby Folfax (voice)
Tim Allen
Meldar Prime (voice)
Alyssa Milano
April (voice)
Carlos Alazraqui
Sr. Estevez (voice)
Jeff Bennett
Gorlock #2 / Brain #1 (voice)
Megan Cavanagh
Judy Neutron / Mrs. Vortex (voice)
Jim Cummings
Brain #2 / Mayor Quadar (voice)
Mark DeCarlo
Hugh Neutron / Emergency System / Gen. Abercrombie (voice)
Jess Harnell
Meldar Prime (singing voice)
Joe Lala
Sr. Estevez (voice)
Phil LaMarr
Bolbi Stroganofsky / British Tourist (voice)
Billy West
Sam / Corky Shumatsu (voice)
Grey DeLisle
Vendanna (voice)