Sylvia Sidney
Jennie Gerhardt
Donald Cook
Lester Kane
Mary Astor
Letty Pace
Edward Arnold
Sen. Brander
H.B. Warner
William Gerhardt
Theodore von Eltz
Robert Kane
Dorothy Libaire
Louise Kane
Louise Carter
Mrs. Gerhardt
Jane Darwell
Boardinghouse Keeper (uncredited)
Frank Reicher
Old Weaver (uncredited)
Betsy Ann Hisle
Veronica Gerhardt (uncredited)
Edward LeSaint
Lester's Doctor (uncredited)
Morgan Wallace
O'Brien (uncredited)
Cora Sue Collins
Vesta at Age 6