Matthew McConaughey
Joseph "Coop" Cooper
Anne Hathaway
Dr. Amelia Brand
Jessica Chastain
Murphy "Murph" Cooper
Michael Caine
Professor John Brand
Bill Irwin
TARS (voice)
Ellen Burstyn
Old Murph
Mackenzie Foy
Young Murph
Casey Affleck
Tom Cooper
John Lithgow
Donald
Wes Bentley
Doyle
David Gyasi
Romilly
Matt Damon
Mann
Topher Grace
Getty
Timothée Chalamet
Young Tom
David Oyelowo
School Principal
William Devane
Williams
Josh Stewart
CASE (voice)
Collette Wolfe
Ms. Hanley
Leah Cairns
Lois
Russ Fega
Crew Chief
Lena Georgas
Nurse Practitioner
Jeff Hephner
Doctor
Elyes Gabel
Administrator
Brooke Smith
Nurse
Liam Dickinson
Coop
Francis X. McCarthy
Boots
Andrew Borba
Smith
Flora Nolan
Girl on Truck
Griffen Fraser
Boy on Truck
William Patrick Brown
NASA Employee (uncredited)
Kristian Van der Heyden
Scientist (uncredited)
Joseph Oliveira
Astronaut (uncredited)
Ryan Irving
Popcorn Seller (uncredited)
Alexander Michael Helisek
Construction Boss (uncredited)
Benjamin Hardy
NASA Scientist (uncredited)