Ray Romano
Manny (voice)
John Leguizamo
Sid (voice)
Denis Leary
Diego (voice)
Goran Visnjic
Soto (voice)
Jack Black
Zeke (voice)
Cedric the Entertainer
Carl (voice)
Stephen Root
Frank / Start (voice)
Diedrich Bader
Oscar (voice)
Alan Tudyk
Lenny / Oscar / Dab (voice)
Lorri Bagley
Jennifer (voice)
Jane Krakowski
Rachel (voice)
Peter Ackerman
Dodo / Macrauchenia (voice)
P.J. Benjamin
Dodo (voice)
Josh Hamilton
Dodo / Aardvark (voice)
Chris Wedge
Dodo / Scrat (voice)
Denny Dillon
Glyptodon (voice)
Mitzi McCall
Glyptodont (voice)
Tara Strong
Baby Moeritherium (voice)
Darin De Paul
Additional Voices (voice) (uncredited)
Dann Fink
Dodo (voice) (uncredited)
Patrick Pinney
Various Mammals (uncredited)
Phil Proctor
Various Mammals (uncredited)