Bruce Willis
Eddie 'Hudson Hawk' Hawkins
Danny Aiello
Tommy Five-Tone
Andie MacDowell
Anna Baragli
James Coburn
George Kaplan
Richard E. Grant
Darwin Mayflower
Sandra Bernhard
Minerva Mayflower
David Caruso
Kit Kat
Frank Stallone Jr.
Cesar Mario
Donald Burton
Alfred
Don Harvey
Snickers
Andrew Bryniarski
Butterfinger
Lorraine Toussaint
Almond Joy
Burtt Harris
Gates
Carmine Zozzora
Antony Mario
Stefano Molinari
Leonardo Da Vinci
Enrico Lo Verso
Apprentice
Remo Remotti
Guy on Donkey
Giselda Volodi
Mona Lisa
P. Randall Bowers
Prison Clerk
Arthur M. Wolpinsky
Prison Security Guard
Frank Page
Mario's Driver
Robert Vazquez
Big Stan
Michael Klastorin
Dean
Scott H. Eddo
Jerry
John Savident
Auctioneer
Lisa Matthews
Girl in Car
John Lucantonio
Vatican Guard
Antonino Iuorio
Vatican Guard
Courtenay Semel
Bratty Kid
Massimo Ciprari
The Pope
Steven M. Martin
Ook
Leonardo Cimino
Cardinal
Giangiacomo Colli
Waiter
Frank Welker
Bunny the Dog (voice)
William Conrad
Narrator (voice)