Bill Murray
Garfield (voice)
Breckin Meyer
Jon
Stephen Tobolowsky
Happy Chapman
Evan Arnold
Wendell
Mark Christopher Lawrence
Christopher Mello
Jimmy Kimmel
Spanky (voice)
Debra Messing
Arlene (voice)
Nick Cannon
Louis (voice)
Alan Cumming
Persnikitty (voice)
Brad Garrett
Luca (voice)
David Eigenberg
Nermal (voice)
Jerry Hauck
Cop
Richard Kind
Dad Rat (voice)
Vanessa Christelle
Miss Ace Hardware
Daamen J. Krall
Announcer
Alyson Stoner
Kid Rat (voice)
Rufus Gifford
Dog Owner #1
Randee Reicher
Dog Owner #2
Eve Brent
Mrs. Baker
Bill Hoag
Roy the Lodge Member
Susan Moore
Dog Owner #4
Ben Kronen
Older Man
Michael Monks
Deputy Hopkins
Mel Rodriguez
Security Officer
Ryan McKasson
Dog Owner #3
Juliette Goglia
Little Girl
Joseph Edward Taylor
Frank