Owen Wilson
Reggie (voice)
Woody Harrelson
Jake (voice)
Amy Poehler
Jenny (voice)
George Takei
S.T.E.V.E. (voice)
Colm Meaney
Myles Standish (voice)
Keith David
Chief Broadbeak (Voice)
Dan Fogler
Governor William Bradford (voice)
Lesley Nicol
Female Pilgrim (voice)
Jimmy Hayward
President of the United States/Ranger/Leatherbeak/Hazmats (voice)
Kaitlyn Maher
President's Daughter (voice)
Carlos Alazraqui
Amos (voice)
Josh Lawson
Gus (Voice)
Dwight Howard
Cold Turkey (Voice)
Danny Carey
Danny (voice)
Carlos Ponce
Narrator/Alejandro (voice)
Robert Beltran
Chief Massasoit (voice)
Scott Mosier
Pizza Dude (voice)