Matthew Modine
Thomas P. Johnson / Voice of Fluke
Nancy Travis
Carol Johnson
Eric Stoltz
Jeff Newman
Max Pomeranc
Brian Johnson
Ron Perlman
Sylvester
Jon Polito
Boss
Bill Cobbs
Bert
Federico Pacifici
Prof. Santini
Clarinda Ross
Jane, Tom's Secretary
Adrian Roberts
Night Guard
Bart Hansard
Day Guard
Deborah Hobart
Dogpound Vet
Libby Whittemore
Libby, the Housekeeper
Collin Wilcox Paxton
Bella
Samuel L. Jackson
Rumbo (voice)
Sam Gifaldi
Young Fluke (voice)