Olympia Dukakis
Emily (Segment 6)
Louis Zorich
Tim (Segment 6)
Adam Rose
Posnick (Segment 1)
Luke Brandon Field
Lerner (Segment 1)
Thomas Mann
Tim (Segment 1)
Zosia Mamet
Emily (Segment 1)
Jeremy Jordan
Phayer (Segment 1)
Alexis Bledel
Emily (Segment 2)
Cara Buono
Emily (Segment 3)
Kal Penn
Tim (Segment 2)
Andre Braugher
Tim (Segment 5)
Phylicia Rashād
Emily (Segment 5)
Kathleen Turner
Narrator
Drena De Niro
Sheilda Posnick (Segment 4)
Dana Eskelson
Sarah (Segment 4)
Dre Davis
Jo Ann (Segment 1)
Dominic Fumusa
Tim (Segment 3)
Adepero Oduye
Meg (Segment 5)
Jennifer Damiano
Helayne Specter
Alexis Molnar
Meg Hanratty (segment 'Betrayal')
Gary Milner
Raymond Phayer (segment 'Betrayal')
Julia K. Murney
Sarah Lerner (segment 'Betrayal')
Malcolm Gets
Emile Hanratty (segment 'Healing')
David Pittu
Tim Hanratty (segment 'Healing')
Richard Joseph Paul
Raymond Phayer (segment 'Healing')
Zainab Jah
Helayne Specter (segment 'Healing')
Alok Tewari
Jon Posnick (segment 'Healing')
Jenny Bacon
Athena Lerner (segment 'Healing')
Edan Alexander
Riley Phayer (segment 'Acceptance')