Jake Gyllenhaal
Donnie Darko
Jena Malone
Gretchen Ross
James Duval
Frank
Drew Barrymore
Karen Pomeroy
Beth Grant
Kitty Farmer
Maggie Gyllenhaal
Elizabeth Darko
Mary McDonnell
Rose Darko
Holmes Osborne
Eddie Darko
Noah Wyle
Prof. Kenneth Monnitoff
Katharine Ross
Dr. Lilian Thurman
Patrick Swayze
Jim Cunningham
Daveigh Chase
Samantha Darko
Arthur Taxier
Dr. Fisher
David St. James
Bob Garland
Patience Cleveland
Roberta Sparrow / Grandma Death
Jazzie Mahannah
Joanie James
Jolene Purdy
Cherita Chen
David Moreland
Principal Cole
Kristina Malota
Susie Bates
Marina Malota
Emily Bates
Scotty Leavenworth
David
Phyllis Lyons
Anne Fisher
Gary Lundy
Sean Smith
Alex Greenwald
Seth Devlin
Stuart Stone
Ronald Fisher
Joan Blair
Mystery Woman
Seth Rogen
Ricky Danforth
Mark Hoffman
Police Officer
Jerry Trainor
Lanky Kid
Tom Tangen
Man in Red Jogging Suit
Carly Naples
Suzy Bailey
Lisa K. Wyatt
Linda Connie
Rachel Winfree
Shanda Riesman
Ashley Tisdale
Kim
Tiler Peck
Beth Farmer
Fran Kranz
Passanger
Sarah Hudson
Friend
Alison Jones
Dorky Half-Sister
Lee Weaver
Leroy
Jack Salvatore, Jr.
Larry Riesman