Johnny Depp
Donnie Brasco / Joseph D. 'Joe' Pistone
Al Pacino
Benjamin 'Lefty' Ruggiero
Michael Madsen
Dominick 'Sonny Black' Napolitano
Bruno Kirby
Nicholas 'Nicky' Santora
James Russo
Paulie
Anne Heche
Maggie Pistone
Zeljko Ivanek
Tim Curley
Brian Tarantina
Bruno
Rocco Sisto
Richard 'Richie' Gazzo
Zach Grenier
Dr. Berger
Gerry Becker
Agent Dean Blandford FBI
Robert Miano
Alphonse 'Sonny Red' Indelicato
Paul Giamatti
FBI Technician
Gretchen Mol
Sonny's Girlfriend
Tim Blake Nelson
FBI Technician
Walt MacPherson
Sheriff
Ronnie Farer
Annette
Terry Serpico
Strip Club Owner
Tony Lip
Philip 'Philly Lucky' Giaccone
George Angelica
Big Trin
Val Avery
Santo Trafficante Jr.
Madison Arnold
Jilly
Delanie Fitzpatrick
Daughter
Katie Sagona
Daughter
Sara Gold
Daughter
Larry Romano
Tommy
James McCauley
FBI Agent
James Bulleit
U.S. Attorney
Andrew Parks
Hollman
Keenan Shimizu
Japanese Maitre D'
Rocco Musacchia
Trafficante's Man
Joe Francis
Trafficante's Man
Sal Jenco
Mare Chiaro Bartender
Billy Capucilli
Communion Party Man
Laura Cahill
Communion Party Woman
Doreen Murphy
Mob Girlfriend
Denise Faye
Mob Girlfriend
Elaine del Valle
Mob Girlfriend
John Horton
FBI Director
Dan Brennan
FBI Photographer
LaJuan Carter
Singer
Sandy Barber
Singer
Joyce Stovall
Singer
Frank Pesce
Wiseguy
Randy Jurgensen
Wiseguy
John Di Benedetto
Wiseguy
Richard Zavaglia
Wiseguy
Tony Ray Rossi
Wiseguy
Edward Black
Wiseguy
Gaetano LoGiudice
Wiseguy
Carmelo Musacchia
Wiseguy
Pat Vecchio
Wiseguy
Caleb
The Lion
Flint Beverage
Kings Court Cop (uncredited)
Frank Bonsangue
Sonny Red's Crew (uncredited)
Mark Todd Bruner
FBI Agent (uncredited)
Teresa Giudice
Shocked Stripper (uncredited)
Barry Hirschberg
Background (uncredited)
Jim Lavin
Arresting FBI Officer (uncredited)
Peter O'Hara
Passerby (uncredited)
Antone Pagán
Prison Guard for Pacino and Depp (uncredited)
Garry Pastore
Carmine Galante's Bodyguard (uncredited)
Dale Resteghini
Strip Club Patron (uncredited)
Larry Tobias
Man in Bar (uncredited)
Elle Alexander
Mob Girlfriend
Frankie Cee
Civilian (uncredited)