Eddie Murphy
Dr. John Dolittle
Ossie Davis
Archer Dolittle
Oliver Platt
Dr. Mark Weller
Peter Boyle
Calloway
Richard Schiff
Dr. Gene Reiss
Kristen Wilson
Lisa
Jeffrey Tambor
Dr. Fish
Kyla Pratt
Maya
Raven-Symoné
Charisse
Steven Gilborn
Dr. Litvack
Erik Dellums
Jeremy
June Christopher
Diane
Cherie Franklin
Mrs. Parkus
Norm Macdonald
Lucky (voice)
Chris Rock
Rodney (voice)
Albert Brooks
Tiger (voice)
Jenna Elfman
Owl (Voice)
Reni Santoni
Rat #1 (Voice)
John Leguizamo
Rat #2 (Voice)
Julie Kavner
Female Pigeon (voice)
Garry Shandling
Male Pigeon (voice)
Ellen DeGeneres
Prologue Dog (voice)
Paul Reubens
Raccoon (voice)
Eddie Frierson
Skunk (voice)
Phil Proctor
Drunk Monkey (Voice)
Gilbert Gottfried
Compulsive Dog (Voice)
Brian Doyle-Murray
Old Beagle (voice)
Douglas Shamburger
Pound Dog (voice)
Jeff Doucette
Possum (voice)
Archie Hahn
Heavy Woman's Dog (voice)
Tom Towles
German Shepherd (voice)
Royce D. Applegate
'I Love You' Dog (voice)
Chad Einbinder
Bettleheim the Cat (voice)
Jonathan Lipnicki
Baby Tiger (voice)
Hamilton Camp
Pig (voice)
Kerrigan Mahan
Penguin (voice)
Mark Adair-Rios
Intern
Don Calfa
Patient at Hammersmith
Kellye Nakahara
Beagle Woman
Beth Grant
Woman
Yule Caise
Vet's Assistant
Charles Branklyn
Security Guard
Richard Penn
Mr. Galvin
Karl T. Wright
Reporter
Stan Sellers
Cop #1
Ming Lo
Cop #2
Paul Giamatti
Blaine (uncredited)
Benny Buettner
Circus Clown (uncredited)
Pruitt Taylor Vince
Patient at Hammersmith (uncredited)
Crystal the Monkey
Drunk Monkey (uncredited)
Kellan Patrick
Jumping Boy (uncredited)
Kay Yamamoto
Receptionist
Brian Kwan
Busboy
L. Peter Callender
Policeman
Arnold F. Turner
Animal Control Officer
Raymond Matthew Mason
3-Year-Old John Dolittle
John Lafayette
Reverend
Phyllis Katz
Goat (voice)
Dari Gerard Smith
5-Year-Old John Dolittle
Bebe Conrad
Circus Clown (uncredited)
Cliff McLaughlin
Mounted Policeman
James F. Dean
Orangutan (voice)