George Clinton
Host
Robert Guillaume
Gleason Golightly (segment 'Space Traders')
Michele Lamar Richards
Gail Golightly (segment 'Space Traders')
Jason Bernard
Bernard Shields (segment 'Space Traders')
Edward Edwards
Chief of Staff (segment 'Space Traders')
George Wallace
Piggy (segment 'Space Traders')
Brian Reddy
Vice President (segment 'Space Traders')
Larry Anderson
Stryker O'Rourke (segment 'Space Traders')
Brock Peters
Minister Coombs (segment 'Space Traders')
Bob Gunton
President Ellis (segment 'Space Traders')
Nicholas Turturro
Father Carlos (segment 'The First Commandment')
Efrain Figueroa
Padrino (segment 'The First Commandment')
Richard Herd
Cardinal (segment 'The First Commandment')
Paula Jai Parker
Tang (segment 'Tang')
Chi McBride
T-Bone (segment 'Tang')
Bertice Berry
(segment 'Space Traders')
Franklin Cover
(segment 'Space Traders')
Casey Kasem
(segment 'Space Traders')
Roxie Roker
(segment 'Space Traders')
Ebonie Smith
Jennifer (segment 'Space Traders')
Craig Kirkwood
Lenny (segment 'Space Traders')
Liz Larou
Ute (segment 'Space Traders')
Jaye Koch
Alien Press Secretary (segment 'Space Traders')
Tom Williams
Education Secretary (segment 'Space Traders')
Marte Boyle Slout
Helen Hipmeyer (segment 'Space Traders')
Joseph G. Medalis
Defense Secretary (segment 'Space Traders')
James Noah
Interior Secretary (segment 'Space Traders')
Tom Finnegan
General Wright (segment 'Space Traders')
Arthur Burghardt
Justin Jasper (segment 'Space Traders')
Roger Guenveur Smith
Dr. Erik Fanon (segment 'Space Traders')
Roger Marks
Rabbi Spector (segment 'Space Traders')
Lamont Johnson
Civil Rights Leader (segment 'Space Traders')
Jedda Jones
Woman in Audience (segment 'Space Traders')
Robert Covarrubias
Hispanic Leader (segment 'Space Traders')
Cynthia Madvig
Cigarette Girl (segment 'Space Traders')
Jim Jansen
Liquor Company CEO (segment 'Space Traders')
Dennis Howard
Petroleum Co. CEO #1 (segment 'Space Traders')
Paul Kent
Petroleum Co. CEO #2 (segment 'Space Traders')
Steve Stapenhorst
Home Products CEO (segment 'Space Traders')
Ann Walker
Audience Member #1 (segment 'Space Traders')
Myra J.
Audience Member #2 (segment 'Space Traders')
J. Kenneth Campbell
Mr. Spivey (segment 'The First Commandment')
Daryl Mitchell
Mover #1 (segment 'The First Commandment')
Eugene Allen
Mover #2 (segment 'The First Commandment')
Noëlle Balfour
The Saint (segment 'The First Commandment')
Robert Wisdom
Captain Jackson (segment 'The First Commandment')
Marcus Salgado
Young Man in the Botanica (segment 'The First Commandment')
George Logan
Male Drug Dealer (segment 'The First Commandment')
Kelly Jo Minter
Female Drug Dealer (segment 'The First Commandment')
Ana Mercedes
Blessed Woman (segment 'The First Commandment')
John Witherspoon
Homeless Man #1 (segment 'The First Commandment')
Chino 'Fats' Williams
Homeless Man #2 (segment 'The First Commandment')
Bowlegged Lou
Homeless Man #3 (segment 'The First Commandment')
Peter Allen Vogt
T.V. Reporter (segment 'The First Commandment')
Roma Alvarez
Old Lady at Church (segment 'The First Commandment')
Paul Anthony
Crack House Thug #1 (segment 'The First Commandment')
B-Fine
Crack House Thug #2 (segment 'The First Commandment')
Tony Canty
Santeria Practitioner (segment 'The First Commandment')
Janus Brown
Santeria Practitioner (segment 'The First Commandment')
Bobby Mateos
Santeria Practitioner (segment 'The First Commandment')
Joey DeLeon
Santeria Practitioner (segment 'The First Commandment')
Robert Melendez
Santeria Practitioner (segment 'The First Commandment')
Margaux Dinerman
Santeria Practitioner (segment 'The First Commandment')
Noah Nichel
Santeria Practitioner (segment 'The First Commandment')
Felicidad Gongora
Santeria Practitioner (segment 'The First Commandment')
Henry Williams
Santeria Practitioner (segment 'The First Commandment')
Irma Williams
Oshun (segment 'The First Commandment')
Reno Wilson
The Messenger (segment 'Tang')