Roberto Benigni
Roberto (segment "Strange to Meet You")
Steven Wright
Steven (segment "Strange to Meet You")
Joie Lee
Good Twin (segment "Twins")
Cinqué Lee
Evil Twin (segment "Twins") / Kitchen Guy (segment "Jack...")
Steve Buscemi
Danny (segment "Twins")
Iggy Pop
Iggy (segment "Somewhere in California")
Tom Waits
Tom (segment "Somewhere in California")
Joseph Rigano
Joe (segment "Those Things'll Kill Ya")
Vinny Vella
Vinny (segment "Those Things'll Kill Ya")
Vinny Vella, Jr.
Vinny Jr. (segment "Those Things'll Kill Ya")
Renee French
Renée (segment "Renée")
E.J. Rodriguez
Waiter (segment "Renée")
Alex Descas
Alex (segment "No Problem")
Isaach De Bankolé
Isaach (segment "No Problem")
Cate Blanchett
Cate / Shelly (segment "Cousins")
Michael Hogan
Waiter (segment "Cousins")
Jack White
Jack (segment "Jack Shows Meg His Tesla Coil")
Meg White
Meg (segment "Jack Shows Meg His Tesla Coil")
Alfred Molina
Alfred (segment "Cousins?")
Steve Coogan
Steve (segment "Cousins?")
Katy Hansz
Katy (segment "Cousins?")
The GZA
GZA (segment "Delirium")
RZA
RZA (segment "Delirium")
Bill Murray
Bill Murray (segment "Delirium")
William Rice
Bill (segment "Champagne")
Taylor Mead
Taylor (segment "Champagne") (voice)