Anthony Gonzalez
Miguel Rivera (voice)
Gael García Bernal
Héctor (voice)
Benjamin Bratt
Ernesto de la Cruz (voice)
Alanna Ubach
Mamá Imelda Rivera (voice)
Renée Victor
Elena Rivera (voice)
Ana Ofelia Murguía
Mamá Socorro "Coco" Rivera (voice)
Edward James Olmos
Chicharrón (voice)
Jaime Camil
Papá Enrique Rivera (voice)
Alfonso Arau
Papá Julio Rivera (voice)
Herbert Siguenza
Tío Oscar Rivera / Tío Felipe Rivera (voice)
Lombardo Boyar
Mariachi / Gustavo (voice)
Sofía Espinosa
Mamá Luisa Rivera (voice)
Dyana Ortelli
Tía Victoria Rivera (voice)
Gabriel Iglesias
Head Clerk (voice)
Selene Luna
Tía Rosita Rivera (voice)
Natalia Cordova-Buckley
Frida Kahlo (voice)
Carla Medina
Departure Agent (voice)
Luis Valdez
Tío Berto Rivera / Don Hidalgo (voice)
Blanca Araceli
Emcee (voice)
Polo Rojas
Abel Rivera (voice)
Montse Hernandez
Rosa Rivera (voice)
Octavio Solis
Arrival Agent (voice)
Cheech Marin
Corrections Officer (voice)
Salvador Reyes
Security Guard (voice)
John Ratzenberger
Juan Ortodoncia (voice)
Daniel Edward Mora
Additional Voices (voice)