Tom Hanks
Dr. Henry Goose / Hotel Manager / Isaac Sachs / Dermot Hoggins / Cavendish Look-a-Like Actor / Zachry
Halle Berry
Native Woman / Jocasta Ayrs / Luisa Rey / Indian Party Guest / Ovid / Meronym
Jim Broadbent
Captain Molyneux / Vyvyan Ayrs / Timothy Cavendish / Korean Musician / Prescient 2
Hugo Weaving
Haskell Moore / Tadeusz Kesselring / Bill Smoke / Nurse Noakes / Boardman Mephi / Old Georgie
Jim Sturgess
Adam Ewing / Poor Hotel Guest / Megan's Dad / Highlander / Hae-Joo Chang / Adam / Zachry Brother-in-Law
Bae Doona
Tilda / Megan's Mom / Mexican Woman / Sonmi-451 / Sonmi-351 / Sonmi Prostitute
Ben Whishaw
Cabin Boy / Robert Frobisher / Store Clerk / Georgette / Tribesman
James D'Arcy
Young Rufus Sixsmith / Old Rufus Sixsmith / Nurse James / Archivist
Zhou Xun
Talbot / Hotel Manager / Yoona-939 / Rose
Keith David
Kupaka / Joe Napier / An-kor Apis / Prescient
Susan Sarandon
Madame Horrox / Older Ursula / Yusouf Suleiman / Abbess
Hugh Grant
Rev. Giles Horrox / Hotel Heavy / Lloyd Hooks / Denholme Cavendish / Seer Rhee / Kona Chief
David Gyasi
Autua / Lester Rey / Duophsyte
Robert Fyfe
Old Salty Dog / Mr. Meeks / Prescient 1
Martin Wuttke
Mr. Boerhaave / Guard / Leary the Healer
Robin Morrissey
Young Cavendish
Brody Nicholas Lee
Javier Gomez / Jonas / Zachry's Older Nephew
Ian van Temperley
Enforcer
Amanda Walker
Veronica
Ralph Riach
Ernie
Andrew Havill
Mr. Hotchkiss
Tanja de Wendt
Mrs. Hotchkiss
Raevan Lee Hanan
Little Girl with Orison at Papa Song's / Catkin / Zachry Relative
Götz Otto
Groundsman Withers
Niall Greig Fulton
Haskell Moore's Dinner Guest / Mozza Hoggins
Louis Dempsey
Haskell Moore's Dinner Guest / Jarvis Hoggins
Martin Docherty
Haskell Moore's Dinner Guest / Eddie Hoggins
Alistair Petrie
Haskell Moore's Dinner Guest / Musician / Felix Finch / Lascivious Businessman
Zhu Zhu
Megan Sixsmith / 12th Star Clone
Sylvestra Le Touzel
Haskell Moore's Dinner Guest / Nurse Judd / Aide in Slaughtership
Jojo Schöning
Papa Song Punk
Laura Vietzen
Young Ursula
Thomas Kügel
Vater
Marie Rönnebeck
Ursula's Daughter
Ruby Kastner
Young Girl
Emma Werz
Ursula's Granddaughter
Mya-Lecia Naylor
Miro
Korbyn Hawk Hanan
Adam Grandson
Katy Karrenbauer
Axwoman
Dulcie Smart
Ursula's Mother / Herbalist
Anna Holmes
Scientist / Executive
Shaun Lawton
Secretary
Moritz Berg
Porter
Gigi Lee
Zachry Relative
Genevien Lee
Zachry Relative
Cody Benjamin Lee
Zachry Relative
Heike Hanold-Lynch
Ms. Judd Look-a-like
Victor Solé
Mr. Roderick
Kristoffer Fuss
Lead Enforcer
Marco Albrecht
Scan Enforcer
Gary McCormack
Crane Operator
David Mitchell
Union Spy