David Mattey
Toxic Avenger / Noxious Offender
Debbie Rochon
Ms. Weiner
Clyde Lewis
Toxie (voice)
Heidi Sjursen
Sarah / Claire
Tom Fulp
Painter
Paul Kyrmse
Sgt. Kabukiman / Evil Kabukiman
Stan Lee
Prologue / Epilogue Narrator
Joe Fleishaker
Chester / Lardass
Dan Snow
Sgt. Kazinski
Michael Budinger
Tito
Lisa Terezakis
Sweetie Honey
Barry Brisco
Pompey
Corey Feldman
Sarah's Gynecologist
Trent Haaga
Tex Diaper
Mark Torgl
Evil Melvin
Rick Collins
Amortville Police Chief
Mitch Cohen
Lucifer
Lisa Gaye
Abortion Counselor
James Gunn
Dr. Flem Hocking
Taylor Mead
Award Presenter
Yaniv Sharon
Rex Diaper
Will Keenan
Man Hit by Car
Melissa Bacelar
Dr. Hocking's Nurse
Jasi Cotton Lanier
Wet Lesbian
Lemmy
Good Lemmy / Bad Lemmy
Julie Strain
Herself (Facelift Death)
Kevin Eastman
Himself (Breast Smoosh Death)
Tiffany Shepis
Beautiful Interpretative Dancer
Eli Roth
Beautiful Young Boy
Hugh Hefner
President of the United States
Charlotte Kaufman
Tromaville / Amortville Citizen
Lloyd Kaufman
Man in Public Service Announcement
Neriah Davis
Glamorous Gyno-American
Devin DeVasquez
Glamorous Gyno-American
Taimie Hannum
Glamorous Gyno-American
Doria Rone
Glamorous Gyno-American
Petra Verkaik
Glamorous Gyno-American
Celeste Octavia
Glamorous Gyno-American / Naked Nurse (as Celeste Octavian)
Tromelissa Saytar
Lesbian Art Student
Terri Firmer
Wet Lesbian / Topless Deaf Translator
Bella Compagna
Diaper Mafia Temptress
Brandi Brandt
Glamorous Gyno-American
Randy Sklar
Randy Diaz
Jason Sklar
Jason Gonzalez