Jeff Goldblum
Professor Brody
Elizabeth Perkins
Mrs. Brody
Alexander Pollock
Scotty Brody
Miriam Margolyes
Sophie the Castle Maid
Tobey Maguire
Lou the Beagle (voice)
Alec Baldwin
Butch (voice)
Sean Hayes
Mr. Tinkles (voice)
Susan Sarandon
Ivy (voice)
Joe Pantoliano
Peek (voice)
Michael Clarke Duncan
Sam (voice)
Jon Lovitz
Calico (voice)
Charlton Heston
The Mastiff (voice)
Glenn Ficarra
Russian Blue (voice)
John Michael Higgins
Ginger Kitten (voice)
Richard Steven Horvitz
Puppy in Barn (voice)
Frank Welker
Buddy (voice)
Frank C. Turner
The Farmer
Kirsten Robek
Pie Mom (as Kirsten Robek)
Mar Andersons
Guard at Gate
Gillian Barber
Factory Receptionist
Carol Ann Susi
Sophie's Sister
Randi Kaplan
Sophie's Sister
Mary Bogue
Sophie's Sister
Alvin Sanders
Mason Employee
Mark Schooley
Mason Employee
Lou Bollo
Worker
Scott Nicholson
Worker
Trish Schill
Worker
Babe Dolan
Wife Passenger
Reg Glass
Truck Driver (as Reginald Glass)
Charles Andre
Truck Driver
Peggy Logan
Nurse
Alicia Michelle
Jogger
Pamela Perry
Yorkie Dog Owner
Victor Wilson
Doberman Drill Sergeant (voice)
Salome Jens
Collie at HQ (voice)
Danny Mann
Ninja Cat (voice)
Billy West
Ninja Cat (voice)
Paul Pape
Wolf Blitzer (voice)
Myron Natwick
Mr. Mason
Doris Chillcott
Mrs. Calvert