Wesley Snipes
Eric Brooks / Blade
Jessica Biel
Abigail Whistler
Ryan Reynolds
Hannibal King
Kris Kristofferson
Abraham Whistler
Dominic Purcell
Dracula / Drake
Parker Posey
Danica Talos
Natasha Lyonne
Sommerfield
James Remar
Ray Cumberland
John Michael Higgins
Dr. Edgar Vance
Patton Oswalt
Hedges
Callum Keith Rennie
Asher Talos
Paul Michael Lévesque
Jarko Grimwood
Françoise Yip
Virago
Mark Berry
Chief Martin Vreede
Paul Anthony
Wolfe
Michael Anthony Rawlins
Wilson Hale
Ginger Page
Zoe
Eric Bogosian
Bentley Tittle
Erica Cerra
Goth Vixen Wannabe
Clay Cullen
Stone
Shannon Powell
Woman Bystander
Birkett Turton
Dingo
Brian Steele
Drake Creature (uncredited)
Christopher Heyerdahl
Caulder