Drew Barrymore
Chloe (voice)
Piper Perabo
Rachel Ashe Lynn
Andy García
Delgado (voice)
George Lopez
Papi (voice)
Paul Rodríguez
Chico (voice)
Plácido Domingo
Monte (voice)
Edward James Olmos
Diablo (voice)
Loretta Devine
Delta (voice)
Jamie Lee Curtis
Aunt Viv
Luis Guzmán
Chucho (voice)
Eddie 'Piolin' Sotelo
Rafa (voice)
Carlos Juvera
Tomás (voice)
Grey DeLisle
Mother Dog (voice)
Manolo Cardona
Sam Cortez
Leslie Mann
Bimini (uncredited)
Cheech Marin
Manuel (voice)
Michael Urie
Sebastian (voice)
José María Yázpik
Vasquez
Maury Sterling
Rafferty
Jesús Ochoa
Officer Ramirez
Eugenio Derbez
Store Owner
Omar Leyva
Ranger
Naomy Romo
Ranger
Ali Hillis
Angela
Marguerite Moreau
Blair
Nick Zano
Bryan
Gina Gallego
Shelter Director
Alberto Reyes
Bellman
Brandon Keener
Waiter
Sal Lopez
Ring Announcer
Giovanna Acha Aleman
Museum Guide
Jack Plotnick
Dog Nanny
Randall England
Butler
James P. Bennett
Bull Fighter (uncredited)