Steve Carell
David Sheff
Timothée Chalamet
Nic Sheff
Maura Tierney
Karen Barbour
Amy Ryan
Vicki Sheff
Christian Convery
Jasper Sheff
Oakley Bull
Daisy Sheff
Kaitlyn Dever
Lauren
Stefanie Scott
Julia
Julian Works
Gack
Jack Dylan Grazer
12-Year-Old Nic Sheff
Zachary Rifkin
8-Year-Old Nic Sheff
Kue Lawrence
5-Year-Old Nic Sheff
Timothy Hutton
Dr. Brown
Amy Forsyth
Diane
Andre Royo
Spencer
Ricky Low
Destiny
LisaGay Hamilton
Rose
Carlton Wilborn
Vince
Amy Aquino
Annie Goldblum
Marypat Farrell
Julia's Mother
Cheska Corona
Kid
Mandeiya Flory
Kid
Martha T. Newman
Flight Attendant
Minerva García
Nurse @ Bellevue
Nikki Snipper
Airline Attendant
Anastasia Leddick
Speaker @ 12 Step Meeting
Edward Fletcher
Minister
Justin Townes Earle
Wedding Guest
Seann Gallagher
Father @ Graduation
Brooklin Thacher
Principal @ Graduation
Tom Beyer
Meeting Leader
David Mendenhall
Rocker (uncredited)