Freddie Highmore
Arthur Montgomery
Madonna
Princess Selenia (voice)
Mia Farrow
Daisy Suchot
Jimmy Fallon
Betameche (voice)
David Bowie
Maltazard (voice)
Doug Rand
Arthur's Father
Penny Balfour
Rose Montgomery
Ron Crawford
Archibald Suchot
David Suchet
Narrator (voice)
Jason Bateman
Prince Darkos (voice)
Adam LeFevre
Davido
Robert De Niro
King (voice)
Snoop Dogg
Max (voice)
Jean Bejote Njamba
Chief Matassalai (voice)
Lee Delong
Saleslady
Saul Jephcott
Police Officer #1
Christian Erickson
Antique Dealer
Eric Balliet
Mover #1
Oxmo Puccino
Mover #2
Robert William Bradford
Baliff
Jerry Di Giacomo
Repairman
Bienvenue Kindoki
Matassalai #1
Valéry Koko Kingue
Matassalai #2
Aba Koïta
Matassalai #3
Vincent Mendy
Matassalai #4
Mathar Licka Gueye
Matassalai #5
Tonio Descanvelle
Police Officer #2
Emilio Estevez
Ferryman
Harvey Keitel
Miro
Rob Corddry
Seides
Nate Corddry
Seides
Erik Per Sullivan
Baby Bug / Mino (voice)
Chazz Palminteri
Travel Agent (voice)
Anthony Anderson
Koolomassai (voice)