Tom Cruise
Barry Seal
Sarah Wright
Lucy Seal
Domhnall Gleeson
Monty Schafer
Alejandro Edda
Jorge Ochoa
Jesse Plemons
Sheriff Downing
Connor Trinneer
George W. Bush
Mauricio Mejía
Pablo Escobar
Jayma Mays
Dana Sibota
Lola Kirke
Judy Downing
April Billingsley
Jenny
Jayson Warner Smith
Bill Cooper
William Mark McCullough
Pete Dubois
Lara Grice
Female Reporter (uncredited)
Frank Licari
ATF Special Agent Franks
Jed Rees
Louis Finkle
Benito Martinez
James Rangel
Justice Leak
Agent Winter
Sharon Conley
DEA Agent Grace (uncredited)
Mike Pniewski
Willie
Robert Pralgo
Gary
E. Roger Mitchell
Agent Craig McCall
Morgan Hinkleman
Christina Seal
Courtney Lakin
Stewardess
Chris Gann
Donor #2 (uncredited)
Fredy Yate
Carlos Lehder
Robert Farrior
Oliver North
Alberto Ospino
Manuel Noriega
Felipe Bernedette
Translator
Daniel Lugo
Adolfo Calero
Lauren Boyd
Secretary
Nancy Reagan
Herself (archive footage)
Lauren Revard
Teller
Marcus Hester
Parka
Alex Collins
ATF #1
Scott Poythress
ATF #2
Alpha Trivette
Judge Linkletter
Kevin L. Johnson
Agent Horace Wainwright
DeVere Jehl
Plain Clothed Man
Emilio Sierra
Héctor (Colombian Driver)
Leon Lamar
Elderly Man
Maria Howell
NSC Woman
Darla Delgado
Customs Agent
Mickey Sumner
North's Aide Fawn Hall
Daniel Thomas May
CIA Man
Chloe Swan Sparwath
LeAnn
Alex Quarles
Aaron
Trip McCarthy
Dean
Zachary Powell
Dean
Jairo Ordóñez
Scar
Matt Mercurio
FBI Analyst
Johnny Otto
Protester
Ronald Reagan
Himself (archive footage)
Kayla Perkins
Waitress (uncredited)
Michael Mercaldi
Sandinista (uncredited)
Dan Southworth
Agent Winters (uncredited)
Bill Billions
Radar Op. #1 (uncredited)