Storm Reid
Meg Murry
Oprah Winfrey
Mrs. Which
Reese Witherspoon
Mrs. Whatsit
Mindy Kaling
Mrs. Who
Levi Miller
Calvin O'Keefe
Deric McCabe
Charles Wallace Murry
Chris Pine
Dr. Alex Murry
Gugu Mbatha-Raw
Dr. Kate Murry
Zach Galifianakis
The Happy Medium
Rowan Blanchard
Veronica Kiley
Michael Peña
Red
André Holland
Principal Jenkins
Bellamy Young
Camazotz Woman
David Oyelowo
The It (voice)
Conrad Roberts
Elegant Man
Lyric Wilson
Young Meg
Yvette Cason
Mrs. Teacher
Will McCormack
Mr. Teacher
Daniel MacPherson
Calvin's Father
Akemi Look
Air Force Officer
Tim Kang
School Superintendent
Michele Norris
Radio News Broadcaster (voice)
Claire Montwill
Student
Catelynn Brown
Meg Double
Ariyah Brown
Meg Double
Losa Fifita
Meg Double
Joyce Larkin
Mrs. Who Double
Teonee Motley
Mrs. Which Double
Jessica Rockwell
Mrs. Whatsit Double
Oz Kalvan
Charles Wallace Double
Isaac Ordonez
Charles Wallace Double
Kai Miller
Charles Wallace Double
Leighton Leevard
Charles Wallace Double
Guillaume Seeleuthner
Charles Wallace Double
Jacob Eddington
Charles Wallace Double
Easton Tath
Baby Charles Wallace
Giselle Paredes
Baby Charles Wallace
