Keir Dullea
Dr. David Bowman
Gary Lockwood
Dr. Frank Poole
William Sylvester
Dr. Heywood Floyd
Douglas Rain
HAL 9000 (voice)
Daniel Richter
Moonwatcher
Leonard Rossiter
Dr. Andrei Smyslov
Margaret Tyzack
Elena
Robert Beatty
Dr. Ralph Halvorsen
Sean Sullivan
Dr. Roy Michaels
Frank Miller
Mission Controller
Ed Bishop
Aries-1B Lunar Shuttle Captain
Edwina Carroll
Aries-1B Stewardess
Heather Downham
Stewardess
Penny Brahms
Stewardess
Maggie London
Stewardess
Chela Matthison
Stewardess
Judy Kiern
Voiceprint Identification Girl
Alan Gifford
Poole's Father
Ann Gillis
Poole's Mother
Vivian Kubrick
Floyd's daughter (uncredited)
Kenneth Kendall
BBC-12 Announcer
Kevin Scott
Miller
Martin Amor
Interviewer Martin Amor
Bill Weston
Astronaut
Glenn Beck
Astronaut
Mike Lovell
Astronaut
John Ashley
Ape
Jimmy Bell
Ape
David Charkham
Ape
Simon Davis
Ape
Jonathan Daw
Ape
Péter Delmár
Ape
Terry Duggan
Ape Attacked by Leopard
David Fleetwood
Ape
Danny Grover
Ape
Brian Hawley
Ape
David Hines
Ape
Tony Jackson
Ape
John Jordan
Ape
Scott MacKee
Ape
Darryl Paes
Ape
Joe Refalo
Ape
Andy Wallace
Ape
Bob Wilyman
Ape
Richard Woods
Ape Killed by Moon-Watcher
S. Newton Anderson
Young Man (uncredited)
Sheraton Blount
(uncredited)
Ann Bormann
(uncredited)
Julie Croft
(uncredited)
Penny Francis
(uncredited)
Marcella Markham
(uncredited)
Irena Marr
Russian Scientist (uncredited)
Krystyna Marr
Russian Scientist (uncredited)
Kim Neil
(uncredited)
Jane Pearl
(uncredited)
Penny Pearl
(uncredited)
Burnell Tucker
TMA-1 Site Photographer (uncredited)
John Swindells
TMA-1 Site Technician #1 (uncredited)
John Clifford
TMA-1 Site Technician #2 (uncredited)
Stanley Kubrick
(voice) (uncredited)
Anthony Jackson
Ape
Frank W. Miller
Mission Controller
Harry Fielder
Moonwalker (uncredited)