Andrew Garfield
Peter Parker / Spider-Man
Emma Stone
Gwen Stacy
Rhys Ifans
Dr. Curt Connors / The Lizard
Martin Sheen
Uncle Ben
Sally Field
Aunt May
Denis Leary
Captain Stacy
Irrfan Khan
Rajit Ratha
Max Charles
Peter Parker (Age 4)
Campbell Scott
Richard Parker
Embeth Davidtz
Mary Parker
Chris Zylka
Flash Thompson
C. Thomas Howell
Jack's Father
Jake Keiffer
Jack
Hannah Marks
Missy Kallenback
Kari Coleman
Helen Stacy
Michael Barra
Store Clerk
Leif Gantvoort
Cash Register Thief
Andy Pessoa
Gordon
Kelsey Asbille
Sally Avril
Kevin McCorkle
Mr. Cramer
Andy Gladbach
Physics Nerd
Ring Hendricks-Tellefsen
Physics Nerd
Barbara Eve Harris
Miss Ritter
Stan Lee
School Librarian
Danielle Burgio
Nicky's Girlfriend
Tom Waite
Nicky
Keith Campbell
Car Thief
Steve DeCastro
Car Thief Cop
Jill Flint
Receptionist
Mark Daugherty
OsCorp Intern
Milton González
Rodrigo Guevara
Skyler Gisondo
Howard Stacy
Charlie DePew
Philip Stacy
Jacob Rodier
Simon Stacy
Vincent Laresca
Construction Worker
Damien Lemon
Taxi Driver
Ty Upshaw
Police Officer with Sketch
James Chen
Police Officer
Alexander Bedria
Officer (SWAT)
Tia Texada
Sheila (Subway)
Jay Caputo
Subway Guy
John Burke
Newscaster (News Chopper)
Terry Bozeman
Principal
Jennifer Lyons
Second Girl (Subway)
Michael Massee
Man in the Shadows
Amber Stevens West
Ariel
Max Bogner
Scientist (uncredited)
Ethan Cohn
Lab Technician (uncredited)
Miles Elliot
Billy Connors (uncredited)
Miranda LaDawn Hill
Cheerleader (uncredited)
Amanda MacDonald
Goth Girl (uncredited)
Maury Morgan
Tina (uncredited)
Michael Papajohn
Alfie (uncredited)