Michael J. Fox
Chance (voice)
Sally Field
Sassy (voice)
Don Ameche
Shadow (voice)
Kevin Chevalia
Jamie Seaver
Benj Thall
Peter Burnford
Veronica Lauren
Hope Burnford
Kim Greist
Laura Burnford-Seaver
Robert Hays
Bob Seaver
Jean Smart
Kate
Gary Taylor
Frank
Anne Christianson
Research Assistant
Ted D'Arms
Vet
Don Alder
Molly's Father
Ed Bernard
Desk Sergeant
William Phipps
Quentin
Frank Welker
Special Vocal Effects (voice)
Bart the Bear
Bear
Woody Eney
Forest Ranger 'Mark'
Rich Hawkins
Forest Ranger
Nurmi Husa
The Caterer
Jane Jones
Molly's Mother
David MacIntyre
Foote
Kit McDonough
Female Forest Ranger
Mary Marsh
Laura's Mom
Glenn Mazen
Minister
Janet Penner
Bob's Mom
Dorothy Roberts
Peter's Teacher
Caroll Spinney
Dog in Pound (uncredited)
Mark L. Taylor
Officer Kirkwood