Joaquin Phoenix
Theodore Twombly
Scarlett Johansson
Samantha (voice)
Amy Adams
Amy
Rooney Mara
Catherine Klausen
Chris Pratt
Paul
Olivia Wilde
Blind Date
Matt Letscher
Charles
Portia Doubleday
Surrogate Date Isabella
Spike Jonze
Alien Child (voice)
Bill Hader
Chat Room Friend #2 (voice)
Kristen Wiig
SexyKitten (voice)
Artt Butler
Text Voice (voice)
SoKo
Isabella (voice)
Brian Cox
Alan Watts (voice)
Luka Jones
Mark Lewman
Sam Jaeger
Dr. Johnson
Pramod Kumar
Pizza Vendor
Evelyn Edwards
Mother Who Dated Pricks
Lil Buck
Busker / Dancer
Lynn Adrianna
Letter Writer #1
Lisa Renee Pitts
Letter Writer #2
Gabe Gomez
Letter Writer #3
May Lindstrom
Sexy Pregnant TV Star
David Azar
Theodore's Divorce Attorney
Guy Lewis
Marriage Counselor
Melanie Seacat
Nice Lady
Steve Zissis
New Sweet Boyfriend of Mother Who Dated Pricks
Dane White
Son
Nicole Grother
Daughter
James Ozasky
Catherine's Dad
Samantha Sarakanti
Mother of Newborn
Gracie Prewitt
Jocelyn (Birthday Girl)
Claudia Choi
Uncomfortable Waitress
Laura Kai Chen
Tatiana
Wendy Leon
Grocery Shopper
Brian D. Johnson
OS1 Commercial Lead
Robert Benard
Michael Wadsworth (Editor)
Lisa Cohen
Michael Wadsworth's Wife
Grant Samson
Michael Wadsworth's Associate